Chulalongkorn combats cancer in lab animals with plant-based antibody

For the first time in Thailand, lecturers at Chulalongkorn University’s Faculty of Pharmaceutical Sciences have efficiently developed antibody from tobacco plants with inhibitory results on the growth of cancer cells in laboratory animals. This signals hope for entry to efficient cancer medicine and therapy at a decrease cost.
From Unsung -class success in producing a COVID-19 vaccine from tobacco vegetation, right now researchers from Baiya Phytopharm Co., Ltd., a Thai company beneath Chulalongkorn University, have reached another milestone in the analysis and development of antibody medication from tobacco plants, which have been found to reduce the scale and inhibit the growth of cancer cells in laboratory animals.
“Our analysis staff has developed the know-how and system to provide plant proteins to make antibody medication, with the hope to help reduce the price of drug manufacturing so that cancer patients in the country can entry drugs more easily and widely,” Assoc. Prof. Dr. Waranyoo Phoolcharoen of Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, spoke of the aims of conducting biopharmaceutical analysis for most cancers immunotherapy therapy.
The potential of this research has lately been acknowledged by a 2023 analysis award from the National Research Council of Thailand (NRCT).
Assoc. Prof. Dr. Waranyoo explains immunotherapy for most cancers: “Cancer is caused by cancer cells binding to cells within the immune system and blocking the functioning of cells in the body. The generally recognized chemotherapy uses drugs to kill most cancers cells within the body. For immunotherapy or cell remedy, however, the purpose is not to destroy cancer cells, however stimulate the immune cells within the patient’s immune system to strengthen, thus blocking cancer cells from binding to cells in the immune system and permitting the system to handle cancer cells by itself.”
Immunotherapy is becoming increasingly well-liked, but the antibody drugs it makes use of are very costly.“ The production process still is dependent upon overseas technology. The tools and tradition media utilized in cell tradition and the growth of the manufacturing scale with cell culture techniques contribute to high production prices, making the medicines accordingly expensive.”
A analysis staff led by Assoc. Prof. Dr. Waranyoo focuses on the manufacturing of antibody medication utilizing native expertise to reduce prices and permit extra sufferers to have entry to medicine.
With assist from CU Enterprise, Assoc. Prof. Dr. Waranyoo oversees the Research Unit for Plant-produced Pharmaceuticals works towards the development and production of recombinant proteins, secondary metabolites, and plant viruses via plant biotechnology, using crops such as tobacco as hosts to produce medicine and vaccines.
The tobacco used is an Australian species known as Nicotiana benthamiana. Assoc. Prof. Dr. Waranyoo argued that bacterium could enter the plant easily and the strain may produce large amounts of the drugs wanted.
“We use crops as factories to supply the proteins we want. We insert antibody–producing genes into tobacco crops in order for the tobacco crops to produce the antibodies (drugs) we want. The extracted protein (antibody) is then purified. We discovered that the antibodies produced by the plants can bind to proteins on the surface of immune cells.”
Assoc. Prof. Dr. Waranyoo referred to the analysis leads to laboratory animals, “The antibodies that the research staff produced from plants can inhibit the expansion of cancer cells in 4 laboratory animals. The measurement of the tumor cells in mice decreased. This capability to make cells shrink in dimension is corresponding to that of the medication used in the market.”
The subsequent steps of the research, Assoc. Prof. Dr. Waranyoo mentioned testing for safety and toxicity and studying the construction of the drug. All knowledge should be submitted to the Food and Drug Administration (FDA) before receiving approval for testing in people.
“If this research is successful, we will produce our own medicines regionally, reducing the price of drug manufacturing and lowering medicinal bills. More people will then have access to most cancers medicines.”
Apart from cancer, the technology to produce antibodies from plant proteins can additionally be used to develop medication or vaccines for a lot of different diseases. Researchers are presently finding out the treatment and prevention of ailments which would possibly be notably problematic in growing countries, similar to rabies. HFMD, Ebola, Nipah, etc.
Assoc. Prof. Dr. Waranyoo emphasises that the final word objective in attempting to innovate and develop medicine is to build strength and stability in medicine and medical therapy for Thai folks. Thai researchers have the potential and know-how to develop aggressive medicine to attain this aim..

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